Venture

Cultured meat startup Prolific Machines unveils its ‘Henry Ford approach’ to cell growth

Comment

Prolific Machines cultured meat
Image Credits: Prolific Machines

The global cultured meat market is poised to reach half a billion dollars by 2030; however, this kind of technology is still very much in the R&D phase for a lot of companies that have emerged over the past five years.

Cultured meat, also known as cultivated meat, is animal meat, but instead of slaughtering the animal to get it, cells are collected from the animal and cultivated in a lab where they are then assembled into a structure of tissue that resembles the same meat we all eat.

We’ve seen a few cultured meat companies unveil their products. For example, Novel Farms has a pork loin, while Bluu Seafood, a German company developing lab-grown seafood, debuted its fish sticks and fish balls last month. Same for Dutch-based Meatable with its sausages, SCiFi Foods with its burgers, and chicken for UPSIDE Foods.

However, the manufacturing process for cultured meat has historically been “both very difficult and very expensive,” Prolific Machines’ co-founder and CEO Deniz Kent told TechCrunch. That’s what his company is out to change.

“You have to use these growth media proteins which are some of the most expensive things — one of the proteins we are replacing is like 30,000 times more expensive than a gram of gold,” he added. “It’s really hard to scale anything for this reason because you have to use these proteins.”

Novel Farms flexes its pork loin ‘muscle’ following future equity investment

Kent, who has expertise in stem cell biology, explained that these proteins have been used for decades, mainly in the biopharmaceutical industry. The technology works on pharmaceutical products that have big budgets, but not so good when you are trying to make a high-volume, low-margin product like meat, he added.

While having the idea for better proteins, he met physicist Max Huisman and machine learning engineer Declan Jones and convinced them to quit their jobs and form Prolific Machines with him in 2020.

That said, Prolific Machines believes it has a unique manufacturing approach for cultured meat cells and is coming out of stealth mode with $42 million in combined seed and Series A funding to build what Kent calls an “assembly line for biology.”

The company aims to do for biology what Henry Ford did for automobiles at the turn of the 20th century. Its technology, still in its early stages, is a way to grow and control cells without the need for any of those expensive recombinant proteins for cell production, he said. Prolific Machines will bring products to market, but will also license its infrastructure to other cultured meat companies.

“Back then, nobody really owned cars apart from super-rich people. What really changed things was Ford,” Kent said. “They built the assembly line for cars and found a way to manufacture cars at a price that normal people could afford. That transformed the industry because then you went from hundreds of car companies to only three companies having over 70% of the market.”

He believes the same thing is going to happen in the cultured meat industry: There are hundreds of companies right now, but “most of them will die because they won’t have a way to manufacture cultured meat cheap enough. The ones that can find a way will survive,” he added.

Prolific Machines was part of SOSV’s IndieBio program in 2021. SOSV led Prolific Machines’ pre-seed round. Meanwhile, for its new capital infusion, the seed-round portion was led by Arvind Gupta, partner at Mayfield, and the Series A by Bill Gates–founded Breakthrough Energy Ventures.

“I never intended to invest in another cultured meat company, but when Deniz showed me what they were doing, I was blown away by the creativity in their approach to reinvent the assembly line for food production,” Gupta said in a written statement. “It is my goal to help reverse climate change by partnering with incredible teams, and I am convinced Prolific Machines will be a winner in the race for sustainable food production.”

Joining in on the two rounds was a group of VC firms and individual investors, including David Adelman, Mark Cuban, The Kraft Family, David Rubenstein, Michael Rubin, Breyer Capital, The SALT Fund, Purple Orange Ventures, Fred Blackford, Jake Poliskin, Matt Katz and Baruch Future Ventures. Add to that a group of celebrities and restaurateurs, including Kevin Love, Tobias Harris, Meek Mill, Ciara and Russell Wilson, Emily Ratajkowski, Maverick Carter, Sean Feeney, Michael Schulson, Mark Bucher and RJ Melman.

Kent said the Series A was raised a year ago, but the company is coming out of stealth now as it prepares to raise a quite hefty “$170 million-ish” Series B in the first quarter of 2023. The new funding will go toward building a 25,000-square-foot headquarters in Emeryville, California, and ramp up hiring to expand its assembly line programs, including fish, poultry and beef.

Meanwhile, he expects the facility to be done in spring 2023. Plans for the company’s first product include an unstructured Wagyu, which means ground meat. Prolific Machines also has a number of high-profile chefs — none that Kent could name now — who have agreed to partner with the company and use its first cultured meat products.

Is cell-cultured meat ready for prime time?

More TechCrunch

The struggle isn’t universal, however.

Connected fitness is adrift post-pandemic

Featured Article

A comprehensive list of 2024 tech layoffs

The tech layoff wave is still going strong in 2024. Following significant workforce reductions in 2022 and 2023, this year has already seen 60,000 job cuts across 254 companies, according to independent layoffs tracker Layoffs.fyi. Companies like Tesla, Amazon, Google, TikTok, Snap and Microsoft have conducted sizable layoffs in the first months of 2024. Smaller-sized…

1 hour ago
A comprehensive list of 2024 tech layoffs

HoundDog actually looks at the code a developer is writing, using both traditional pattern matching and large language models to find potential issues.

HoundDog.ai helps developers prevent personal information from leaking

The changes are designed to enhance the consumer experience of using Google Pay and make it a more competitive option against other payment methods.

Google Pay will now display card perks, BNPL options and more

Few figures in the tech industry have earned the storied reputation of Vinod Khosla, founder and partner at Khosla Ventures. For over 40 years, he has been at the center…

Vinod Khosla is coming to Disrupt to discuss how AI might change the future

AI has already started replacing voice agents’ jobs. Now, companies are exploring ways to replace the existing computer-generated voice models with synthetic versions of human voices. Truecaller, the widely known…

Truecaller partners with Microsoft to let its AI respond to calls in your own voice

Meta is updating its Ray-Ban smart glasses with new hands-free functionality, the company announced on Wednesday. Most notably, users can now share an image from their smart glasses directly to…

Meta’s Ray-Ban smart glasses now let you share images directly to your Instagram Story

Spotify launched its own font, the company announced on Wednesday. The music streaming service hopes that its new typeface, “Spotify Mix,” will help Spotify distinguish its own unique visual identity. …

Why Spotify is launching its own font, Spotify Mix

In 2008, Marty Kagan, who’d previously worked at Cisco and Akamai, co-founded Cedexis, a (now-Cisco-owned) firm developing observability tech for content delivery networks. Fellow Cisco veteran Hasan Alayli joined Kagan…

Hydrolix seeks to make storing log data faster and cheaper

A dodgy email containing a link that looks “legit” but is actually malicious remains one of the most dangerous, yet successful, tricks in a cybercriminal’s handbook. Now, an AI startup…

Bolster, creator of the CheckPhish phishing tracker, raises $14M led by Microsoft’s M12

If you’ve been looking forward to seeing Boeing’s Starliner capsule carry two astronauts to the International Space Station for the first time, you’ll have to wait a bit longer. The…

Boeing, NASA indefinitely delay crewed Starliner launch

TikTok is the latest tech company to incorporate generative AI into its ads business, as the company announced on Tuesday that it’s launching a new “TikTok Symphony” AI suite for…

TikTok turns to generative AI to boost its ads business

Gone are the days when space and defense were considered fundamentally antithetical to venture investment. Now, the country’s largest venture capital firms are throwing larger portions of their money behind…

Space VC closes $20M Fund II to back frontier tech founders from day zero

These days every company is trying to figure out if their large language models are compliant with whichever rules they deem important, and with legal or regulatory requirements. If you’re…

Patronus AI is off to a magical start as LLM governance tool gains traction

Link-in-bio startup Linktree has crossed 50 million users and is rolling out the beta of its social commerce program.

Linktree surpasses 50M users, rolls out its social commerce program to more creators

For a $5.99 per month, immigrants have a bank account and debit card with fee-free international money transfers and discounted international calling.

Immigrant banking platform Majority secures $20M following 3x revenue growth

When developers have a particular job that AI can solve, it’s not typically as simple as just pointing an LLM at the data. There are other considerations such as cost,…

Unify helps developers find the best LLM for the job

Response time is Aerodome’s immediate value prop for potential clients.

Aerodome is sending drones to the scene of the crime

Granola takes a more collaborative approach to working with AI.

Granola debuts an AI notepad for meetings

DeepL, which builds automated text translation and writing tools, has raised a $300 million round led by Index Ventures.

AI language translation startup DeepL nabs $300M on a $2B valuation to focus on B2B growth

Praktika has secured a $35.5M Series A round to apply AI-powered avatars to language-learning apps.

Praktika raises $35.5M to use AI avatars to make learning languages feel more natural

Humane, the company behind the hyped Ai Pin that launched to less-than-glowing reviews last month, is reportedly on the hunt for a buyer.

Humane, the creator of the $700 Ai Pin, is reportedly seeking a buyer

India’s Oyo, once valued at $10 billion, has withdrawn its IPO application from the market regulator for the second time.

Oyo, once valued at $10 billion, shelves IPO plans for second time

Ore Energy emerged from stealth today with €10 million in seed funding. The company hopes to make grid-scale batteries that are cheaper and longer lasting.

Ore Energy emerges from stealth to build utility-scale batteries that last days, not hours

Paytm, a leading financial services firm in India, said its net loss widened in the fourth quarter as it grappled with a regulatory clampdown.

Paytm warns of job cuts as losses swell after RBI clampdown

Government officials and AI industry executives agreed on Tuesday to apply elementary safety measures in the fast-moving field and establish an international safety research network. Nearly six months after the…

In Seoul summit, heads of states and companies commit to AI safety

Copilot, Microsoft’s brand of generative AI, will soon be far more deeply integrated into the Windows 11 experience.

Microsoft wants to make Windows an AI operating system, launches Copilot+ PCs

Some startups choose to bootstrap from the beginning while others find themselves forced into self funding by a lack of investor interest or a business model that doesn’t fit traditional…

VCs wanted FarmboxRx to become a meal kit, the company bootstrapped instead

Uber and Lyft drivers in Minnesota will see higher pay thanks to a deal between the state and the country’s two largest ride-hailing companies. The upshot: a new law that…

Uber’s and Lyft’s ride-hailing deal with Minnesota comes at a cost

Andreessen Horowitz’s American Dynamism fund has established a new fellowship program aimed at introducing top engineers and technologists to venture investing, a move that could help the firm identify less…

a16z’s American Dynamism team launches program to introduce technical minds to VC